Everything about indazole-3-carboxamide
Substitution at R3 with a halogen or alkoxy group (74f–74i) led to a slight increase in mobile potency with the halide analogs (74g–h) demonstrating best the potency from the group. Even further optimization brought about the discovery of 74i–j, with 74k as one of the most active compound within the collection (pIC50 = 6.seventy seven) with v